Recommendation for Immunization:
There are two different formulations of this vaccine. For RotaTeq®, the recommended regimen is a series of 3 vaccines preferably at 2, 4, and 6 months of age. This is not recommended before 6 weeks of age or after 32 weeks of age. It is not recommended to begin a series after 12 weeks of age.
For Rotarix®, the first dose is at 6 weeks of age. The second dose is recommended at least 4 weeks after the first dose, but prior to 24 weeks of age.
For catch-up dosing, please see CDC recommendations.
1. What is this vaccine?
This is a live vaccine against rotavirus infection in infants and children. RotaTeq® protects against infection caused by 4 different serotypes G1, G2, G3, and G4. Rotarix® protects against infection caused by 4 different serotypes G1, G3, G4, and G9.
2. Why do I need this vaccine?
This vaccine is needed to prevent rotavirus, the most common cause of severe diarrhea in children. Other symptoms include vomiting and fever. Often rotavirus infections occur from November to May. In some children, this virus can lead to hospitalization and even death.
3. How is the vaccine given?
The vaccine is a liquid that comes in a single dose latex-free tube with a twist-off cap and the liquid is squeezed direcly into the mouth towards the inner cheek.
4. What are the risks and special considerations of this vaccine?
It is recommended that children not get this vaccine if they have ever had a case of intussusception, a rare form of intestinal blockage. This complication was occasionally seen with an older formulation of the vaccine. Children who have HIV/AIDS, cancer, immune system problems, or recent transfusion of any blood product may not be able to get this vaccine: check with the doctor. This vaccine is very safe, but side effects can occur. There can be mild, temporary diarrhea, or vomiting up to 7 days after the dose.
Individuals with prior severe reactions to this vaccine may not be able to receive another dose. Check with your doctor regarding this issue and for any other contraindications for this vaccine. Also check with your doctor to find out what other ingredients may be in the vaccine, its container, or any diluent in case of allergies or other concerns. Immunization is usually postponed for individuals with a moderate or severe acute illness.
5. Risk factors for contraction of disease:
- Infants and children, especially < 3 years of age
- Elderly
- Immunocompromised
Citations
- "Recommended Immunization Schedule for Persons Aged 0-18 Years, United States 2008." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. May 2008. http://www.cdc.gov/vaccines/recs/schedules/downloads/child/2008/08_11x17_booklet_pr.pdf.
- "Recommended Adult Immunization Schedule — United States, October 2007–September 2008." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. October 2007. www.cdc.gov/mmwr/pdf/wk/mm5641-Immunization.pdf.
- "Rotavirus." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. National Center for Infectious Diseases. Respiratory and Enteric Viruses Branch. June 2008. www.cdc.gov/rotavirus/.
- "RotaTeq® (Rotavirus Vaccine, Live, Oral, Pentavalent)." Merck and Co., Inc. July 2008. http://www.merck.com/product/usa/pi_circulars/r/rotateq/rotateq_pi.pdf.
- "Rotavirus Vaccine What You Need To Know." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. National Immunization Program. Vaccine Information Statement (Interim). April 2006. www.cdc.gov/vaccines/pubs/vis/downloads/vis-rotavirus.pdf.
- "Who Should NOT Get Vaccinated with these Vaccines?" Centers for Disease Control and Prevention. U.S. Department of Health and Human Services. October 2007. http://www.cdc.gov/vaccines/vpd-vac/should-not-vacc.htm.
- "Rotarix®." GSK. April 2008. http://us.gsk.com/products/assets/us_rotarix.pdf.
- "Rotavirus vaccines (Rotarix and RotaTeq) for prevention of rotavirus gastroenteritis." National Prescribing Service Limited. January 2007. http://www.nps.org.au/health_professionals/publications/nps_radar/issues/current/july_2007/rotavirus_vaccines.
- "Vaccine Excipient and Media Summary." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-1.pdf.
- "Vaccine Excipient and Media Summary, Part 2." U.S. Department of Health and Human Services. Centers for Disease Control and Prevention. April 2008. http://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf.
- "Thimerosol in Vaccines." U.S. Food and Drug Administration. Center for Biologics Evaluation and Research. June 2007. http://www.fda.gov/cber/vaccine/thimerosal.htm.
Created: 7/2/2007
Last Modified: 8/12/2008